Once you have imported the URLs you wish to profile, it is simply a case of selecting which datapoints you wish to pull back - either at a domain level or a URL level.
Warning: Don't just tick every single box. All this does is make the software run slower, use up more CPU resources, and waste your API credits.
Pick the specific datapoints you wish to return for the specific task you are carrying out.
When you have selected these, hit 'Run Profiler' to get going.
The length of time it takes to complete will depend upon how many URLs you have selected, how many different datapoints you have asked the software to return, and how powerful your computer is.